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Relationship between Environmental Exposure and Biological Exposure Indices(BEls) in Laminating Procedure Workers Exposed to Styrene

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KMID : 0613219960140000177
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Abstract

This is an effort to confirm changes biological exposure indices(BEIs) according to changes in levels of exposure to styrene for laminating workers. This study was
conducted on 79 workers, including male of 35 and female 44 who were working at factories of FRP. The data were collected and analyzed during June-September 1995.
Sociodemographic and behavioral variables were obtained from survey using by interviewing subjects with questionnaire. An improved passive monitor method
(organic vapor monitor; OVM) was employed to determine levels of exposure. The biological monitoring indices include blood styrene concentration, urinary mandelic
acid(MA), and urinary phenylglyoxylic acid(PGA). BEIs were made through the collection of blood and urine.
The mean value of exposure to styrene was 26.5ppm, which is measured by organic vapor monitor, one of improved passive monitors. The highest exposure level was
observed among workers in boat factories, nonprocessing workers, respectively (pitem time weighted average(TWA). The correlation coefficient between biological monitoring indices and the exposure level was 0.60 for blood styrene concentration, 0.55 for MA corrected by creatinine, and 0.76 for PGA corrected by creatinine, respectively(p<0.01). The regression analyses found exposure level relative importance in explaining variance in biological monitoring indices. In additional to that, gender was a significant factor in explaining variance of Blood styrene. About 37% of variance in biological monitoring indices was accounted by exposure level, age, gender, and accumulative exposure indices level(p<0.01). Almost half of variance(60%) in PGA concentration was explained by predictors, including exposure level, age, gender, duration, and drinking volume during the last week(p<0. 01).
In conclusion, exposure level may be predicted on MA, PGA in urine and blood styrene concentration, which could be applied to represent BEIs.
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